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2020 Volume 11 Issue 1

Parkinson Disease, Recent Updates: Literature Review


Emad F. A. Aljarbou, Ziyad A. S. Alosayfir, Albaraa A. M. Johali, Shumukh F. Alshammari, Nairooz M. Alzamzami, Ahmed A. A. Alabdulmuhsin, Fatima M. Alshammari, Abdullah A. Aljulajle, Abdulrahman A. H. Al Sharbi, Afnan H. A. Madkhali, Abeer R. Alanzi
Abstract

Background: Parkinson's Disease (PD) is considered a chronic progressive neurodegenerative disorder and it can affect both motor and nonmotor functions. Around one million Americans have the disease and 1-3% of the individuals who are older than 60 years of age of the general population are affected worldwide. The progression of PD, from the first damage of the nervous system cells to the appearance of clinical symptoms, takes a considerable long period. Therefore, it is very important to identify the affected individuals before the appearance of the clinical manifestations to start protective strategies as early as possible. Objective: To evaluate Parkinson's disease, pathophysiology, symptomology, and management in the published and provide an adequate review tackling these topics. Method: PubMed database was used for article selection, and the following keys were used in the mesh ((“Parkinson Disease"[Mesh]) AND (“management”[Mesh]) OR (“evaluation"[Mesh])). Conclusion: The treatment of PD is symptoms-based and the medications are targeted toward the dopaminergic pathway. The most effective treatment for PD is levodopa. It treats most of the symptoms successfully. However, levodopa is associated with severe adverse effects. Therefore, other medications such as Monoamine Oxidase B (MAO-B) inhibitors and dopamine agonists can be started to delay the need for levodopa. A non-medical approach such as physical therapy and exercise is recommended along with medical therapy.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative