Objective: The aim of this study is to determine the role of plasma C-reactive protein (CRP), Procalcitonin (PCT), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels in diagnosing ventilator-associated pneumonia.Methods: A total 95 patients admitted to Intensive Care unit (ICU) were divided into VAP positive group (N=50) and VAP negative group (n=45) based on CPIS scoring system. Demographic data, causes of admission, underlying disease were recorded. Serum level of biomarkers were measured after admission to ICU.Results: Serum CRP and PCT levels of patients in the VAP positive group were significantly higher than those without VAP group (P value<0.05). Serum level of sTREM-1 didn’t have significant differences between two groups. The most common cause of admission in ICU was neurological abnormalities. Age, sex, duration of admission and underlying diseases didn’t have relation with biomarker value.Conclusion: This study found that elevated CRP and PCT serum level provide superior markers to sTREM-1 to predict VAP patients in ICUs. Probably more comprehensive designed studies are needed to achieve a better and earlier way to diagnose VAP.
