TY  - JOUR
T1  - Biochemical Interaction Analysis of Natural SGLT2 Inhibitors with Alzheimer Targets: A Computational Approach
A1  - Ahmed Alafnan
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2020
VL  - 11
IS  - 4
SP  - 73
EP  - 84
N2  - Alzheimer’s Disease (AD) is a progressive neurological disorder, and its association with type 2 diabetes mellitus (T2DM) has increased its intricacy to many folds. Thus, targeting both associated disorders with a single therapeutic agent appears to be promising. Anti-AD potency of a new class of anti-diabetic agents, i.e., Sodium-Glucose Co-transporters 2 (SGLT2) inhibitors have been investigated in the present study. The docking approach was applied to elucidate the interaction pattern of natural SGLT2 inhibitors (Acerogenin A, Alstiphyllanine D, ε-viniferin, Phlorizin, and Sophoraflavanone G) with AD targets. Here, Acerogenin A, ε-viniferin and Sophoraflavanone G showed better binding with almost all AD targets as compared to positive controls, except β-secretase where positive control verubecestat showed better results than these inhibitors. Also, ε-viniferin and Sophoraflavanone G have shown potency against direct amyloidβ aggregation. We state that SGLT2 inhibitors based scaffolds could be explored to develop dual therapeutic agents against T2DM and AD.
UR  - https://jbiochemtech.com/article/biochemical-interaction-analysis-of-natural-sglt2-inhibitors-with-alzheimer-targets-a-computational-approach
ER  -