TY  - JOUR
T1  - Severe Generalized Tetanus in an Adolescent Following Delayed Post-Exposure Prophylaxis in Kyrgyzstan: A Case Report
A1  - Mamatkulova Nazgul Mamatkulovna
A1  - Abdimomunova Begimai Toktobolotovna
A1  - Zholdoshev Saparbai Tezekbayevich
A1  - Utepbergenova Gulmira Alkenovna
A1  - Kudabay Aliya Userbaevna
A1  - Eman Firdous
A1  - Myrzabekova Aizhamal Chikalovna
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2025
VL  - 16
IS  - 4
DO  - 10.51847/PtUHo7y9uL
SP  - 122
EP  - 127
N2  - Tetanus is a serious, but not the most common, infection, which can be deadly in the age of universal immunization. The patient represents a clinical case of severe generalized tetanus in a 15-year-old adolescent who contracted the disease due to a puncture wound to the foot without receiving prophylaxis immediately after contact. The case highlights that tetanus is an epidemiologically relevant disease in people who are not fully vaccinated or who have not received booster injections. This illness was described as typical 8-10 days following trauma and was typified by traditional indicators of generalized tetanus, comprising trismus, severe muscle spasms, risus sardonicus, tonic convulsions, and consciousness preservation. The observed clinical manifestation was in line with the established neurotoxicity of tetanospasmin on the inhibitory mechanisms via the central nervous system. The patient was admitted and treated in an intensive care unit. Having antitetanus serum, antibacterial treatment, infusion support, sedation, and muscle relaxants were all taken into account as extensive treatment. The patient underwent constant examination, and their condition improved, avoiding the development of critical complications. This case study brings to the fore the significance of wound management, especially in the management of puncture wounds, prompt prophylaxis administration of tetanus in case of supposedly infected wounds, and following booster vaccinations in the adolescent stage strictly. Even the individual instances are to be viewed as signs of possible lapses in vaccination coverage. During active tetanus prevention and control, constant checking of the vaccination status, raising public awareness on the issue of prophylaxis due to injuries, and long-term clinical monitoring are crucial elements of successful prevention of tetanus as a health condition.
UR  - https://jbiochemtech.com/article/severe-generalized-tetanus-in-an-adolescent-following-delayed-post-exposure-prophylaxis-in-kyrgyzsta-ofxhbikquctq7sb
ER  -