TY  - JOUR
T1  - Scientifically Based Development of an Innovative Gauze Dressing with a Combined Composition for Accelerated Wound Healing
A1  - Hava Ali Kizi Karimova
A1  - Mukhtar Dzheiranov
A1  - Maleika Elnurovna Garaeva
A1  - Turkan Kamandar Kizi Sharifova
A1  - Fizze Ruslanovna Zaidova
A1  - Kseniya Romanovna Korovko
A1  - Olga Vladimirovna Belyakova
A1  - Askar Satkalievich Chumbaev
A1  - Diana Magomedovna Madagova
A1  - Andrey Viktorovich Matyukhin
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2025
VL  - 16
IS  - 2
DO  - 10.51847/jhL1wvJj85
SP  - 132
EP  - 140
N2  - The development of effective and safe means for local wound treatment remains an urgent problem in modern medicine. The purpose of this study was to create an innovative drug in the form of an impregnated gauze bandage, ready for immediate use. The formulation is based on a synergistic combination of zinc sulfathiazole, which provides antimicrobial action and delivery of zinc ions as a regeneration cofactor, dexpanthenol, for direct stimulation of cell proliferation and epithelialization, and standardized tea tree essential oil, which has additional antiseptic and anti–anti-inflammatory activity. The paper presents a proven production technology that guarantees the stability of the composition and sterility of the final product. Analytical control confirmed the compliance of all active substances with the declared specifications (zinc sulfathiazole content 99.8%, dexpanthenol 98.5%) and the absence of dangerous heavy metal impurities. Preclinical studies on the model of full-layered skin wounds in 70 Wistar rats demonstrated a statistically significant superiority of the developed dressing over the control groups (placebo and levomekol group). By day 14, almost complete epithelialization was achieved in the main group (8.7% of the initial wound area), which was accompanied by the formation of mature granulation tissue and minimal inflammatory reaction. Toxicological studies have not revealed signs of systemic toxicity or local irritant effects. The results obtained indicate the high pharmaceutical quality, pronounced regenerative efficacy, and favorable safety profile of the developed dressing, which defines it as a promising agent for wound treatment and justifies the expediency of further clinical studies.
UR  - https://jbiochemtech.com/article/scientifically-based-development-of-an-innovative-gauze-dressing-with-a-combined-composition-for-acc-efafk6wye5wktcc
ER  -