TY  - JOUR
T1  - Prenatal Stress in Repeat Pregnancy: Effects of Vitamins on Offspring Development in Rats
A1  - Nifizat Seyfudinovna Kurbanova
A1  - Amina Zamirovna Azrakuliyeva
A1  - Amina Anzorovna Kvaratskhelia
A1  - Yunus Nadir-Shakhovich Arkallaev
A1  - Madinat Magomedbegovna Magomedova
A1  - Yakha Vahaevna Magomadova
A1  - Yakha As-Salyalovna Kulchieva
A1  - Roza Issaevna Katsieva
A1  - Khadishat Batirovna Mutalieva
A1  - Hyadi Batirovna Mutalieva
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2026
VL  - 17
IS  - 1
DO  - 10.51847/nUBaH7Bh9F
SP  - 79
EP  - 89
N2  - A short interpregnancy interval is a known risk factor for adverse pregnancy outcomes. However, the effectiveness of multivitamin support in women with metabolic depletion from a prior pregnancy and lactation combined with chronic prenatal stress remains poorly understood. This study examined how chronic prenatal stress, modeling a short interpregnancy interval, affects pregnancy and offspring development in rats and whether multivitamins are protective. We used 80 female Wistar rats divided into four groups: control (rested), vitamins (rested), stress (depleted), and stress+vitamins (depleted). We assessed reproductive outcomes, biochemical and hormonal markers, and physical and neuropsychiatric offspring development. Among depleted females exposed to stress, the preterm birth rate reached 35%, the fetal resorption rate 20%, the newborn weight dropped by 28%, and corticosterone levels were 2.4-fold higher than controls. Their offspring showed delayed physical development, slower reflex maturation, and increased anxiety. Multivitamin supplementation reduced preterm births by 15% and resorption by 5%, increased newborn weight by 18%, and improved offspring development. However, none of these parameters reached control levels. In conclusion, multivitamin correction offers only partial protection under conditions of a short interpregnancy interval and chronic prenatal stress. This finding supports a comprehensive clinical approach that includes, alongside vitamin therapy, adequate maternal rest, recovery, and psychosocial support.
UR  - https://jbiochemtech.com/article/prenatal-stress-in-repeat-pregnancy-effects-of-vitamins-on-offspring-development-in-rats-vzqtdvg2g9xgrwi
ER  -