TY  - JOUR
T1  - Exploring the Anesthetic Potential of γ-Hydroxybutyric Acid Derivatives: Synthesis and Biological Evaluation of New Local Anesthetics
A1  - Radima Muratovna Bytdaeva
A1  - Alina Azretovna Kipkeeva
A1  - Dinara Maratovna Tramova
A1  - Rabia Muratovna Bogatyreva
A1  - Milana Mukhamedovna Tieva
A1  - Sabina Zurabovna Lakashiya
A1  - Regina Samyatovna Abdrakhmanova
A1  - Dilara Magomedovna Shikhalieva
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2025
VL  - 16
IS  - 2
DO  - 10.51847/WJkSXrI5qW
SP  - 25
EP  - 32
N2  - This research investigates the therapeutic potential of aqueous Chlorophytum comosum extract in managing bilirubin metabolism disturbances in laboratory animals with experimentally induced toxic hepatitis. The study compared the efficacy of three treatment approaches: Chlorophytum comosum extract monotherapy, standard vitamin therapy (including vitamins B₁, B₂, B₆, B₁₂, PP, E, and C), and a combination of both treatments. The experiment involved four groups of Chinchilla breed rabbits, with toxic hepatitis induced by a single subcutaneous injection of carbon tetrachloride (CCl₄). Blood samples were collected daily to measure total and direct bilirubin levels using the «Lakhema» test method. Key findings revealed that CCl₄ intoxication significantly increased bilirubin levels, primarily affecting direct bilirubin. The highest bilirubin concentrations were observed on the 4th day in untreated rabbits. Notably, the combination therapy group demonstrated the most effective reduction in bilirubin levels by the 10th day of the study. With efficacy comparable to that of regular vitamin therapy and additive benefits when combined, the study underlines the potential of Chlorophytum comosum extract as a promising hepatoprotective drug.  According to these results, extract from Chlorophytum comosum may be a useful supplement in the treatment of toxic liver damage, providing a safe and natural substitute for traditional therapies. The study emphasizes the importance of further research into the hepatoprotective properties of plant-based remedies, particularly in addressing liver damage caused by environmental toxins and industrial pollutants. The results contribute to the growing body of evidence supporting the therapeutic potential of natural compounds in liver disease management.
UR  - https://jbiochemtech.com/article/exploring-the-anesthetic-potential-of-g-hydroxybutyric-acid-derivatives-synthesis-and-biological-ev-lpsidzbs0ynwham
ER  -