TY  - JOUR
T1  - Development of Sedative Chewing Lozenges Based on a Complex of Herbal Extracts and Glycine for Children
A1  - Alzhanat Muratovna Mustafayeva
A1  - Abidat Muratovna Mustafayeva
A1  - Fatima Shamilovna Omargadjieva
A1  - Maperi Vladlenovna Balaeva
A1  - Anastasia Sergeevna Kobiz
A1  - Ksenia Viktorovna Mironenko
A1  - Rasul Takhirovich Chinchiev
A1  - Fatima Magomedovna Budunova
A1  - Bella Usmanovna Girimova
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2025
VL  - 16
IS  - 2
DO  - 10.51847/ZEj8PNyKPw
SP  - 124
EP  - 131
N2  - Sleep disorders and neurotic disorders in children represent a significant medical and social problem. The prevalence of insomnia in the pediatric population reaches 6%. When taking into account concomitant sleep disorders, this indicator increases to 50% among preschool children. Existing therapeutic approaches often require the development of new, safe, and effective remedies with improved compliance characteristics. The purpose of this scientific work is to develop and comprehensively study a new sedative phytopreparation in the form of chewable lozenges based on standardized extracts of Melissa officinalis (Melissa officinalis L.), Polemoniaceae (Polemonium caeruleum L.), and glycine. During the course of the work, the standardization of plant extracts was carried out, and a formulation and technology for producing lozenges were developed. The quality assessment was conducted based on organoleptic, physico-chemical, and microbiological parameters. The pharmacological activity was studied in preclinical studies on a model of white rats (n=30) using the "open field" and "raised cruciform maze" tests. The finished product meets the requirements of the regulatory documentation. Preclinical studies revealed a statistically significant (p
UR  - https://jbiochemtech.com/article/development-of-sedative-chewing-lozenges-based-on-a-complex-of-herbal-extracts-and-glycine-for-child-ycpic0piocj7yea
ER  -