TY  - JOUR
T1  - Development of Chalcone-Aspirin Conjugates: A Novel Approach for Antimicrobial Potential
A1  - Danao Kishor
A1  - Rokde Vidhi
A1  - Thote Lokesh
A1  - Dhabarde Disha
A1  - Kamble Manish
A1  - Darne Chetan
A1  - Baheti Jagdish
A1  - Zanwar Aarti
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2025
VL  - 16
IS  - 3
DO  - 10.51847/azbEVcan0P
SP  - 71
EP  - 81
N2  - Traditional antibiotics are often restricted by resistance, adverse effects, and diminishing potency. Hybrid drug design, which combines two pharmacophores in a single molecule, offers a new alternative. Chalcones, flavonoid derivatives possessing α, β- unsaturated carbonyl system, exhibit antibacterial, anti-inflammatory, and antidiabetic properties. The Claisen-Schmidt condensation is used to synthesize the chalcones, which are then conjugated with aspirin fragments by esterification or amidation reactions. Spectroscopic methods including mass spectrometry, NMR, and infrared spectroscopy are used for structural analysis. The cup plate approach was used to assess the generated compounds' antibacterial activity against E. coli. Antimicrobial activity was determined using molecular docking experiments utilizing PyRx software. Using spectroscopic investigation, including IR, NMR, and mass spectroscopy, as well as preliminary testing, the chalcone-aspirin conjugate was produced and examined. Compound 17 was evaluated for antibacterial effectiveness using the cup plate method and showed a binding affinity of -7.7 kcal/mol against a microbial target by molecular docking. The synthesized chalcone-aspirin conjugates showed promising antibacterial activity, as evidenced by spectroscopic analysis and biological assessment. This work demonstrates the possibility of hybrid drug design for the development of innovative treatment medicines against resistant illnesses.
UR  - https://jbiochemtech.com/article/development-of-chalcone-aspirin-conjugates-a-novel-approach-for-antimicrobial-potential-npwkycdec76ru1z
ER  -