TY  - JOUR
T1  - Biotechnological Systems: Protein Substances Based on Enzymatic Hydrolysis of Collagen, Implementation of Engineering Innovations
A1  - Poznyakovsky Valeriy Mikhailovich
A1  - Kurkina Yulia Yurievna
A1  - Avstrievsky Alexander Nikolaevich
A1  - Tokhiriyon Boisjoni
A1  - Ragozinnikova Elena Viktorovna
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2026
VL  - 17
IS  - 2
DO  - 10.51847/rNztg9p5B3
SP  - 71
EP  - 77
N2  - This research presents a novel biotechnological approach for the development of an 'all-purpose' protein substance, "Metacollagen Silicon+", designed for specialized products with tailored functional properties. The core innovation lies in the enzymatic hydrolysis of animal-derived collagen, primarily bovine gelatin, using fungal alkaline protease (Protosem C). This process is characterized by mild, naturally analogous biochemical conditions, operating without pH pre-adjustment. A key differentiator of this substance is the incorporation of silicon, derived from mineral water sourced from a deep Siberian well, containing a notable concentration of silicic acid (75.7±11.3 mg/L). The resulting "Metacollagen Silicon+" is a mixture of collagen types I, II, and III, exhibiting favorable organoleptic characteristics. The article details the amino acid profile of the hydrolyzed collagen, highlighting the significant presence of glycine, proline, and hydroxyproline, alongside seven essential amino acids crucial for human health. The study elaborates on the multifaceted role of silicon in the body, particularly its importance for epithelial and connective tissues, skin, hair, nails, and bone health, where it interacts with calcium and various micronutrients. Furthermore, the research explores a sustainable practice of repurposing solid gelatin capsules, investigating methods for their purification from synthetic dyes using activated carbon as an effective sorbent. The developed process is implemented at an automated biotechnological facility certified under ISO 22000 and GMP standards, positioning this innovative protein substance as a valuable ingredient for functional foods, dietary supplements, and cosmetic products aimed at improving connective tissue health and bodily appearance.
UR  - https://jbiochemtech.com/article/biotechnological-systems-protein-substances-based-on-enzymatic-hydrolysis-of-collagen-implementati-aarf1httuj3oklg
ER  -