TY  - JOUR
T1  - Analysis of Biological Activity Like Antioxidant, Antimicrobial, and DNA Damage of Paracetamol
A1  - Kalpana Barasker
A1  - Neelu Jain
A1  - Parul Jain
A1  - K. Gour
JF  - Journal of Biochemical Technology
JO  - J Biochem Technol
SN  - 0974-2328
Y1  - 2024
VL  - 15
IS  - 1
DO  - 10.51847/oJqFuut9r0
SP  - 19
EP  - 26
N2  - Paracetamol has been employed over an extensive duration as an analgesic and antipyretic agent. Subsequently, there has been a notable escalation in the incidence of poisoning with paracetamol emerging as the predominant substance in cases of self-poisoning, associated with elevated fatality and morbidity rates. While the utilization, misuse, and strategies for mitigating paracetamol toxicity are under examination, serious consideration should be given to altering the drug's legal classification-potentially transitioning it to a prescription-only status, given the inherent risks. The most effective approach to quantifying the uneven distribution of resultant liver injury involves correlating plasma enzyme activity in the affected liver regions. Although liver glutathione levels decrease similarly with 3% casein + phenobarbitone and yeast diets, animals fed yeast exhibit heightened sensitivity to paracetamol despite lower cytochrome P-450 levels. The addition of methionine to the oral dose of paracetamol proves preventive against fatalities and liver damage, suggesting a potentially valuable strategy for enhancing the safety of paracetamol administration, particularly in cases of potential overdose.
UR  - https://jbiochemtech.com/article/analysis-of-biological-activity-like-antioxidant-antimicrobial-and-dna-damage-of-paracetamol-b4stocgl4tujjgu
ER  -